Product Portfolio

Biosof's customized solutions build on our expertise and our extensive portfolio. Our product portfolio represents a wide array of state-of-the-art computational sequence analysis tools and is the result of decades of cumulative research work. To get further details about Biosof's tools and databases please contact sales@bio-sof.com

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Sequence Analysis
Data Integration
System Biology
Fold Recognition
Databases

Sequence Analysis

PredictProtein is a complete sequence analysis solution that features predictions of secondary structure, solvent accessibility, transmembrane helices and transmembrane strands, beta-membrane proteins, sequence motifs, low-complexity regions, regions lacking regular structure and globular regions, identification of extremely rigid or flexible residues on the protein surface, coiled-coil regions, structural switch regions, disulfide-bonds, nuclear localization signals, sub-cellular localization, and functional annotations. Additional analysis includes fold recognition by prediction-based threading, domain assignments, predictions of residues involved in external protein-protein interactions and inter-residue contacts. For furhter information please visit http://www.predictprotein.org

PROFphd

PROFphd is a world renowned suite of protein structure and function analyses tools. The secondary structure and solvent accessibility predictor utilizes a specialized neural network and provides up to 75% accuracy for homology based profiles.

Data Integration

GeneTegrate is a computational platform providing a unifying semantic modeling layer to enrich, simplify and accelerate the analyses of distributed heterogeneous biological data. GeneTegrate encompasses a semantic modeler, providing a repository of enriched object-relationships schemata to represent raw biological data; a schema (model) definition language and a query language, to represent and manipulate the semantic of biological data; adapters to integrate GeneTegrate with multiple biological databases and analysis tools; and caching mechanisms to accelerate analyses of commonly accessed data. Thus, it is possible using GeneTegrate to access numerous services and integrate their output into a comprehensive representation of all available biological knowledge and types of analysis. For further information please visit http://www.genetegrate.org

System Biology

PiNAT assesses protein protein interaction (PPI) networks and simulates the flow of processes and pathways in the cell. The input to PiNAT a list of protein identifiers. These identifiers are used to query PPI databases, to retrieve all experimentally known interactions, to build a network, and to render this network on the image of a cell according to the predicted localization of the interactions. For further information please visit http://cubic.bioc.columbia.edu/services/pinat/

Fold Recognition

AGAPE

AGAPE is an improved and generalized method for sequence-profile and profile-profile comparisons using sequence and predicted 1D structure (secondary structure and accessibility).

Databases

Epitome is a database of all known antigenic residues and the
antibodies that interact with them, including a detailed description of residues involved in the interaction and their sequence / structure environments. Additionally, Interactions can be visualized using an interface into Jmol. For further information please visit http://www.rostlab.org/services/epitome/